Dehp full form

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DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan circa and in the United States in DEHP has two stereocenters, [8] located at the carbon atoms carrying the ethyl groups.

Dehp full form

Di 2-ethylhexyl phthalate DEHP is a man-made chemical. It is a colorless liquid with a slight odor. DEHP is found throughout the environment at low levels. It gets into the environment mostly through the disposal of plastic waste in landfills. Most DEHP in the environment is found in sediments and soil. It sticks strongly to soil and breaks down slowly when it is near the surface. Indoors, DEHP can also stick to dust particles. DEHP stuck to particles in the air can return to the ground or bodies of water via rain or snow. DEHP does not usually evaporate into the air or easily dissolve in water. It can build up in fish and other water-dwelling species. DEHP is found in many plastic products.

Toxicology Mechanisms and Methods. Environmental Health Perspectives.

If you have any questions, comments, or concerns about the content of this page, please contact us. Di 2-ethylhexyl phthalate DEHP. DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer, and may also harm the male reproductive system. Exposure to DEHP during pregnancy may affect the development of the child. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. What is DEHP?

Context - Diethylhexyl-phthalate DEHP is a substance that is mainly used as an additive in plastics to make them more flexible. Phthalates are widely used as additives in a wide range of plastics and other materials that are found in many consumer products. They make plastics, such as PVC, soft and flexible. As they are not chemically bound to plastics, they can be released from consumer products. There is public concern about phthalates because of their widespread use and occurrence in the environment as well as their potential effects on human health. There is a wide range of different phthalates , each having specific properties, uses, and health effects. In , an estimated one to four million tonnes of DEHP were produced in the world. DEHP is not chemically bound to the polymer products that it is added to.

Dehp full form

The toxicity to exposure ratio for different human populations and scenarios has been used to derive the MOS. For the scenarios on production and industrial use, monitored data for inhalation exposure and modelled values for dermal exposure have been used as a realistic worst case. For the scenario industrial end-use of products containing DEHP, it is assumed that relatively high work temperatures, aerosol generation and considerable skin contact occur. There is not enough quantitative and qualitative information available on technical control measures and personal protective equipment used during production and processing to establish their effectiveness. There is concern for the testicular effects, fertility , toxicity to kidneys, on repeated exposure and developmental toxicity for workers as a consequence of inhalation and dermal exposure during production, processing and industrial end-use of preparations or materials containing DEHP. There is no concern for the acute toxicity, irritation and sensitising effects, carcinogenicity , and mutagenicity. Exposure scenarios considered important for adult consumers concern exposure from indoor air, PVC gloves and car interiors. The information used is based on measurements and modelling of DEHP in indoor air, absorption from gloves and car interiors.

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Signal word. No studies have evaluated the potential for DEHP to cause cancer in humans, while exposure to high doses of DEHP for a long period of time resulted in liver cancer in rats and mice. These studies indicate that the toxic effect of DEHP and its metabolites is different in different species and the toxic effect is related to the dose. Studies in mice have shown other adverse health effects due to DEHP exposure. The total amount of DEHP retained by the patient during the dialysis session ranged from 3. Effects of uterine and lactational exposure to di- 2-ethylhexyl phthalate on spatial memory and NMDA receptor of hippocampus in mice. Mutation Research - Reviews in Mutation Research. Hinton R. Brain-derived neurotrophic factor BDNF is a protein that plays a critical role in the survival of existing neurons and promotes the enhancement and differentiation of new neurons and their synapses [ 73 ]. DEHP makes these plastics softer and more flexible and was first introduced in the s in blood bags. First-trimester DEHP exposure in pregnant women has negative impacts on the offspring that lead to a decrease in the anogenital distance AGD , particularly in newborn boys but not in girls, which implies that exposure to DEHP affects male genital development [ 42 ]. Some animals developed pancreatic and testicular cancer. Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. Based on all the factors explained above, the reduced MR expression in Leydig cells [ 14 ] and decreased aldosterone serum levels [ 19 ], both provoked by DEHP in utero exposure, probably can reduce testosterone levels in adult rats.

DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water.

DEHP can also cause nephropathy in male rats. Environmental health : a global access science source. In men, increased exposure to DEHP has been linked with decreased testosterone and sperm motility, although no evidence of fertility problems has been seen in people. In most animal studies, the exposure amounts to DEHP of the animals were much higher than that in the environment. Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. After weeks of DEHP exposure, kidney weights were significantly lower than those of the controls [ 62 ]. Hannon P. In the past, DEHP was one of the phthalates most frequently used in plastic products, but its use has decreased in recent years for a variety of reasons. The effects of di 2-ethyl hexyl phthalate DEHP on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level. If you have any questions, comments, or concerns about the content of this page, please contact us. Effect of in utero exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: A study in rats using different ways of administration.