Drfive

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Indeed, apoptosis and non-apoptotic signaling can be activated in clonal populations of cancer cells in response to treatment and, as a result, only a part of the initial cellular population dies while a fraction survives and develops resistance to TRAIL-induced apoptosis referred to as 'fractional survival'. Notably, the molecular characterization of the protein platforms streaming into tumoricidal versus tumor-promoting cascades that control fractional survival remained elusive.

Drfive

Your browser does not have JavaScript enabled and some parts of this website will not work without it. For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome. This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free production For more information see here. Our Abpromise guarantee covers the use of ab in the following tested applications. Lanes 1- 2: Merged signal red and green. Green - ab observed at 47 kDa. Loss of signal was observed when knockout cell line ab knockout cell lysate ab was used. Membrane was blocked for 1 hour at room temperature in 0. Confocal image showing cytoplasmic staining on HT cells. The nuclear counter stain is DAPI blue. Lanes 1 - 2 : Merged signal red and green. Red - loading control, ab , observed at 37 kDa.

Trends Mol Med ; 19 : —

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Drfive

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Journal of Cell Communication and Signaling Show results from All journals This journal. Take a look Maybe later. Trends Cell Biol ; 25 : — Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. I agree to the terms and conditions. Supplementary Figure 4 JPG 81 kb. Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Non-lethal outcomes of engaging regulated cell death pathways in cancer Article 05 June Essential for ER stress-induced apoptosis. You are using a browser version with limited support for CSS. Our results are of major importance for the implementation of TRAIL-based cancer-selective therapies and provide a new rationale for the rather disapointing results obtained with TRAIL-therapeutics.

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Subpopulations displaying low survivors, '1' and high apoptotic, '2' levels of PARP cleavage in treated samples are depicted. Anti-N-cadherin antibodies and anti-EEA1 antibodies were used as markers of plasma membrane and early endosomes respectively to verify the purity of the plasma membrane fraction. In parallel 7. Abcam user community Verified customer Submitted Sep 18 Main Tumor necrosis factor-related apoptosis-inducing ligand TRAIL, TNFSF10, Apo2L , a member of the tumor necrosis factor family of cytokines, binds to the extracellular domains of four plasma membrane-bound receptors inducing their oligomerization. Our results are of major importance for the implementation of TRAIL-based cancer-selective therapies and provide a new rationale for the rather disapointing results obtained with TRAIL-therapeutics. Cell Death Differ ; 12 : — Cancer Res ; 67 : — Science ; : — Cell Death Differ ; 21 : — Results TRAIL induces non-apoptotic pathways supporting fractional survival To study the molecular mechanisms underlying fractional survival in response to TRAIL treatment, we used isogenic populations of cancer cells derived from stepwise tumorigenesis models, in which normal cells are transformed into tumorigenic ones by introducing defined genetic elements. Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family. Discussion Following the discovery of 'cancer cell-selective' apoptosis by TRAIL, several strategies have been explored for cancer therapy.