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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome euronetwork published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS, euronetwork.

Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different. The immunological scenario of seronegative PCD seems to be different from that of limbic encephalitis with only few patients harboring anti-neuropile antibodies.

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Close X. Select your language. Log out EU Login Log out. English EN. My subscriptions My saved searches My Booklet My profile. Log in. Fact Sheet Results in Brief Reporting. The database included the 'classical' PNS plus several others, less-well characterised syndromes in association with cancer. Cerebellar degeneration and sensory neuronopathy were the most frequent syndromes followed by limbic encephalitis, Paraneoplastic neurological syndromes PEM and brainstem encephalitis; these classical PNS confirmed the clinical profile already reported in the literature. A remarkable finding in this group of syndromes was the Rankin scale analysis that showed that patients with cerebellar degeneration and Yo antibodies had a higher level of disability than did cases with other onconeural antibodies.

There were no reported cases of poliomyositis, euronetwork. The impression is that VGCK rarely causes paraneoplastic euronetwork encephalitis, although it has been associated with dysautonomia. An additional large number of sensory neuronopathies also had significant motor involvement, and this entity was referred to as sensorimotor neuronopathy, euronetwork.

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31,

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date.

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To accept or reject analytics cookies, turn on JavaScript in your browser settings and reload this page. An additional large number of SNs had significant motor involvement, called sensorimotor neuronopathy. Setting: Twenty European centers. The database was organized in the following 6 main areas: 1 basic patient data, including clinical syndrome and time of symptom onset and diagnosis; 2 laboratory data, including serum and cerebrospinal fluid antibodies and their detection methods; 3 treatment of the neurologic disease and cancer therapy; 4 diagnostic tests, including cerebrospinal fluid analysis, nerve conduction velocities, electromyography, and computed tomography and magnetic resonance imaging brain and spinal ; 5 list of the main types of PNS-related tumors; and 6 cause of death and the availability of autopsy material. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Infrequently, other tumors such as of the prostate, thymus, and testis were observed. The hematologic diseases such as lymphoma and Hodgkin disease rarely manifested as PNS. Anti—NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Paraneoplastic encephalomyelitis was observed in 55 patients, among whom the cerebellum was the most frequent site of involvement The most frequent combinations were limbic encephalitis associated with dysautonomia 8 patients , with PCD 6 patients , and with Lambert-Eaton myasthenic syndrome 5 patients.

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Among the cohort, 1 tumor was found in patients, 2 tumors in 53 patients, and 0 tumors in patients. For patients with available data, the tumor types are listed in Table 4 , which confirms small cell lung cancer, ovary, breast, and non—small cell lung cancer as the malignant neoplasms most frequently associated with PNS, accounting for This PNS Euronetwork study was a longitudinal, nonconcurrent, prospective observational analysis, which does not permit epidemiologic inferences about the overall frequency of PNS. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Log out EU Login Log out. Rent article Rent this article from DeepDyve. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms. Diagnoses were according to the Graus criteria. The relative distribution of disorders confirms cerebellar degeneration and SN as the most frequently appearing types of PNS. The outcome status was available in In patients with PCD, the most frequent findings were subacute onset of moderate Obtained funding : Giometto, Vitaliani, and Honnorat. Accept analytics cookies Reject analytics cookies View cookies.