Free radic res

Federal government websites often end in. The site is secure. Free radicals and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. They are produced either from normal cell metabolisms in situ or from external sources pollution, free radic res, cigarette smoke, radiation, medication.

Free Radical Research , formerly Free Radical Research Communications , is an academic journal that publishes research papers, hypotheses, and reviews on free radicals , redox signaling , antioxidants , and oxidative damage. It is published by Informa Healthcare. Free Radical Research publishes 12 issues per year in simultaneous print and online editions. Contents move to sidebar hide. Article Talk. Read Edit View history.

Free radic res

Free radicals and other reactive oxygen species ROS are constantly formed in the human body. Free-radical mechanisms have been implicated in the pathology of several human diseases, including cancer, atherosclerosis, malaria, and rheumatoid arthritis and neurodegenerative diseases. Catalases in peroxisomes convert H 2 O 2 into water and O 2 and help to dispose of H 2 O 2 generated by the action of the oxidase enzymes that are located in these organelles. Other important H 2 O 2 -removing enzymes in human cells are the glutathione peroxidases. When produced in excess, ROS can cause tissue injury. However, tissue injury can itself cause ROS generation e. Assessment of oxidative damage to biomolecules by means of emerging technologies based on products of oxidative damage to DNA e. Download to read the full article text. Gomberg, M. Article Google Scholar. Hey, D.

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Federal government websites often end in. The site is secure. In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases.

It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypothesis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ionizing irradiation IR -induced Human Lymphocyte AHH-1 cells apoptosis and increase cells viability in vitro. This paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde MDA intestinal 8-hydroxydeoxyguanosine 8-OHDG levels and increase plasma endogenous antioxidants in vivo. It is suggested that hydrogen has a potential as an effective and safe radioprotective agent. Abstract It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro.

Free radic res

Objectives: The goal of our study was to investigate the associations of oxidized LDL apoB aldehyde-modified form and acute phase proteins fibrinogen, CRP with acute ischemic stroke severity and outcome. Materials and methods: The study included 61 ischemic stroke patients and 64 controls. Strokes were subtyped according to TOAST criteria, the severity and outcome of stroke at 1 year were measured. Results: The mean triglyceride, fibrinogen, CRP and glucose values were significantly higher among cases. The median oxLDL value for patients with large artery atherosclerosis LAA type of stroke was significantly higher than for other subtypes. The oxLDL values did not correlate with age, stroke severity and outcome. Conclusions: Inflammatory markers fibrinogen and CRP predicted the stroke severity and outcome whereas elevation of oxLDL levels did not. Our data refer to possibility that there may exist some links between the LAA subtype of stroke and elevated oxLDL apoB aldehyde-modified form. Abstract Objectives: The goal of our study was to investigate the associations of oxidized LDL apoB aldehyde-modified form and acute phase proteins fibrinogen, CRP with acute ischemic stroke severity and outcome. Publication types Research Support, Non-U.

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Lancaster, J. Watts, B. Gaziano, P. Some internally generated sources of free radicals are[ 8 ]. Zheng, M. London: Academic Press; Adkins, J. PubMed Google Scholar. Food Agric. Free radicals and other ROS are derived either from normal essential metabolic processes in the human body or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals. Cancer 18 :1—29

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USA 84 — Oxidative stress plays a major part in the development of chronic and degenerative ailments such as cancer, arthritis, aging, autoimmune disorders, cardiovascular and neurodegenerative diseases. Received Mar 4; Revised Mar 8. Frankl, R. As a library, NLM provides access to scientific literature. The term is used to describe the condition of oxidative damage resulting when the critical balance between free radical generation and antioxidant defenses is unfavorable. Bruckdorfer, Portland Press, London, , pp. Health 10 : — Trends Plant Sci. Metals, toxicity and oxidative stress.