Lymphocytic infiltration

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However, since the original description by Jessner and Kanof in [ 1 ], the existence of JLI as a distinct disease has been questioned [ 2 ]. The list of disorders that overlap clinically and histologically with JLI is vast, indicating that JLI is probably not a separate entity, but rather a clinicopathologic reaction pattern common to different skin diseases [ ]. In the last few decades, significant advancements in the immunopathologic and molecular diagnosis have enabled a specific diagnosis for many of the cases previously labeled as JLI [ ]. Nonetheless, some cases of JLI defy a precise diagnosis. This topic will review the clinical manifestations, diagnosis, differential diagnosis, and management of JLI. Other benign lymphoproliferative skin disorders are discussed separately. See "Cutaneous T cell pseudolymphomas" and "Cutaneous B cell pseudolymphoma".

Lymphocytic infiltration

Jessner lymphocytic infiltration of the skin JLIS is the term used to describe a rare, benign cutaneous condition characterized by papular or plaque-like eruptions that commonly involve sun-exposed areas such as face, neck, and trunk. The eruptions are erythematous, non-scaly, and can also be annular. This disease has an indolent course, lasting weeks to months, and as the eruptions expand peripherally, they can sometimes exhibit central clearing or healing. The eruptions then clear spontaneously, or with the aid of medications, without sequelae but frequently recur. The lesions are usually asymptomatic. However, some patients have complained of burning and pruritus. This disease is diagnosed by biopsy revealing perivascular and periadnexal clusters of plasmacytoid monocytes within the dermis, sometimes extending into the subcutaneous tissue. These cells, also known as plasmacytoid dendritic cells, play a vital role in the induction of autoimmune diseases and other skin diseases. However, there remains the possibility of hereditary and autoimmune components. JLIS, also known as benign lymphocytic infiltration of the skin, Jessner-Kanof syndrome, and benign chronic T-cell infiltrative disease, was first described in by Max Jessner and Norman Kanof. In , the disease was included under the umbrella term cutaneous lymphoid hyperplasia along with lymphocytoma cutis and malignant lymphomas used to encompass skin diseases with lymphocytic infiltrates.

Due to the complication of ectropion, patients with periorbital lesions should be monitored closely.

Degree of lymphocyte infiltration in 8 specimens with cervical node—positive and 12 specimens with cervical node—negative findings in undifferentiated nasopharyngeal cancer. Bar indicates SE; mpf, medium power-fields. Lymphocytic Infiltration in Undifferentiated Nasopharyngeal Cancer. Arch Otolaryngol Head Neck Surg. Background Undifferentiated nasopharyngeal carcinoma NPC is characterized by prominent lymphocytic infiltration. Although the lymphoid infiltrate in NPC has been examined extensively in morphologic and immunocytochemical studies, the significance of this lymphoid infiltrate and its correlation with prognosis has been a subject of controversy for years. Objective To elucidate the significance of lymphoid infiltration in undifferentiated NPC.

This topic will discuss the definition of atypical lymphocytic infiltrate, the difficulties in differentiating reactive lymphocytic infiltrates from early lymphoma from the pathologist and clinician perspective, and the management of patients who receive this ambiguous diagnosis. Mycosis fungoides and other cutaneous lymphoproliferative disorders are discussed separately. Why UpToDate? Learn how UpToDate can help you. Select the option that best describes you. View Topic. Font Size Small Normal Large. Approach to the patient with a diagnosis of atypical lymphocytic infiltrate of the skin. Formulary drug information for this topic. No drug references linked in this topic.

Lymphocytic infiltration

Lymphocytic interstitial pneumonia LIP is lymphocytic infiltration of the alveolar interstitium and air spaces. The cause is unknown. Symptoms and signs are cough, progressive dyspnea, and crackles. Diagnosis is based on history, physical examination, imaging tests, and lung biopsy. Treatment is with corticosteroids, cytotoxic drugs, or both, although efficacy is unknown.

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Thus, the abundant lymphoid infiltrate observed in NPC would play a significant role in the biology of this neoplasm. Annu Rev Immunol. Four categories have been defined depending on the increased, stable, decreased or absence of stained cell between baseline and the last biopsy Additional file 1 : Table S1. Subscribe Sign in. This activity reviews the histopathology, evaluation, and differential diagnoses of this condition and highlights the role of the interprofessional team in evaluating and improving care for patients with this condition. Epub Dec Sorry, a shareable link is not currently available for this article. Histological findings. Textbook of Dermatology. It is a rare disorder in which there is a large increase in the number of B cells. What is Jessner lymphocytic infiltrate? Comments Required Please let us know what's on your mind. Due to the complication of ectropion, patients with periorbital lesions should be monitored closely. Lastly, for patients using medical therapy such as topical steroids and antimalarials, regular follow-up is required to monitor for side-effects like skin atrophy. MHC Class I was evaluated using an intensity criterion instead of the number of positive cells.

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Clinicopathologic and immunologic study of 83 cases. The revelation was standardized for each marker. Received : 25 June Harrington 2. Jessner lymphocytic infiltration of the skin JLIS is a rare, benign skin disorder characterized by asymptomatic, erythematous papular, or plaque-like eruptions. In: StatPearls [Internet]. Some cases of GA may resolve spontaneously within only a few years. However, there remains the possibility of hereditary and autoimmune components. The importance of T cells in tumor immunity, as evidenced by the direct killing of the tumor cells mediated via activated lymphocytes, was demonstrated some 30 years ago. NORD and MedicAlert Foundation have teamed up on a new program to provide protection to rare disease patients in emergency situations. Dermatitis, chronic inflammatory infiltrate of the pilo-sebaceous unit. Lymphocytic infiltration was present in all 20 cases of undifferentiated carcinoma. Acta Dermatovenerol Croat.