Macquarie university dementia research centre

Lars graduated from the University of Ulm in Germany and completed his thesis at the University … View full profile. Yuanyuan completed a PhD in Biomedical Science in Currently a Postdoctoral Fellow at Macquarie Macquarie university dementia research centre in the Dementia Research Centre, focusing on the pathogenesis of Alzheimer's disease and related gene-target therapy. Previously working as a researcher and lecturer at the Key Laboratory … View full profile.

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver. Hence, there is an unmet need for new therapeutic avenues in dementia. The multidisciplinary team of the Dementia Research Centre works closely with medicinal chemists and international pharmaceutical industry to accelerate translation into novel therapies for these devastating diseases. To treat dementia, it is vital to first understand the processes that lead to neuronal dysfunction and brain atrophy. Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia. The current discovery research program of the Dementia Research Centre strives to identify novel disease mechanisms and reveal new avenues to treat these devastating conditions.

Macquarie university dementia research centre

Please also feel free to contact us if you are not eligible for any of the studies below, or if you have any suggestions or questions. We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you. You will also do some cognitive tests, answer questionnaires, provide a blood sample and have some body measurements taken. You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. If you would like to volunteer, please contact the team at: E: adnet. Previous work by Professor Ralph Martins and his team has found that the effects of testosterone therapy may extend to both the accumulation and clearance of amyloid beta from the brain and may potentially prevent the disease. The project will also study the effects of omega-3 fatty acids found in fish oil called DHA Docosahexaenoic Acid. DHA is thought to protect brain cells from the damage caused by the accumulation of amyloid beta. It is hoped that combining fish oil with testosterone will have a stronger preventative effect. Man concerned about their memory, aged 60 to 80, free from any major or unstable medical conditions, who have a testosterone level on the low side of normal, and are not currently taking testosterone treatment. You would like volunteer and do not know your testosterone level; we would still love to hear from you. We will collect a blood sample and test it for you. Participation requires initial screening to identify volunteers who are safe and suitable to take part. This is first done by a phone questionnaire, followed by two clinic visits to discuss the trial and your medical history with a study doctor, blood tests, and memory assessments.

Magdalenas research primarily focuses on identifying, and testing novel treatments for neurodegenerative diseases, as well as utilizing specific models to better understand mechanisms underlying neur… View full profile. Ke group team members. View all 85 research outputs.

The DRC currently includes eight research groups. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. These include small molecules, antibodies and gene therapy approaches. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans.

The treatment works by focusing on a naturally protective enzyme in the brain called p38gamma, which when activated prevents the toxic effects of memory loss. Dementia is the leading cause of death of women and the second leading cause of death of all Australians. Brothers Lars and Arne Ittner, from Macquarie's Dementia Research Centre , have been studying dementia treatments for more than a decade but the breakthrough came when Arne discovered that the gene therapy was able to impact a protective enzyme in the brain with outstanding impacts on memory in advanced dementia. Two months after we treated the mice at very old ages, these mice suddenly behaved like their normal siblings. We were really stoked. It for sure kills you and there is nothing we can do about it. The brothers say that what they have found is better than any hypothesis: the new therapy did not only halt memory loss, it completely reversed the loss already there. A decade's work: Lars and Arne Ittner say the momentous results of the research exceeded their expectations. So, two months after we treated the mice at very old ages, these mice suddenly behaved like their normal siblings.

Macquarie university dementia research centre

Organisational unit : University. Faculty of Medicine, Health and Human Sciences. Organisational unit : Department. Organisational unit : Research Centre. Macquarie University. Organisational unit : Faculty.

Jawbreaker apparel

She completed her PhD in Bioengineering at the Pukyung National University in the Republic of Korea, identifying and characterized genetic marker related disease resistant in fish model. Ittner, L. Andrea is a research assistant responsible for histology and tissue processing at the Dementia Research Centre, Faculty of Medicine and Health Science. Tietz group team members. Daryl Ariawan daryl. These topic labels come from the works of this organisation's members. To overcome these limitations, the Dementia Research Centre has brought together experts in cellular neurobiology and peptide hydrogel chemistry and developed new 3D neuronal culture systems, based on our proprietary matrix technology. E-mail: seonghee. Group leader. Brain neurons remain one of the hardest cell types to culture, due to their inability to multiply and fastidious culturing conditions. Research teams: Ittner group van Eersel group Tietz group.

Hope: Professor Lars Ittner, who has spent 15 years working on unravelling the mysteries of dementia, feels his goal of developing effective drug therapies is now achievable thanks to the team assembled at the new Dementia Research Centre.

These topic labels come from the works of this organisation's members. Organisation profile. Explore network further. In , she completed her Honours project on investigating the spreading of tau protein pathology under the supervision of Prof Lars Ittner. E-mail: sian. Phase 1 clinical trial to investigate the effects of coconut oil specifically medium-chain triglycerides on ketone body production and cognitive function for the prevention of Alzheimer's disease in healthy older adults. Neuropathology provides the unique opportunity to visualise disease-specific protein abnormalities and the cell types and brain regions affected that cause neurodegeneration. Search this site. Techniques to grow neurons in single layers have long been developed but remain both labour and costs-intensive. You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. His thesis dealt with the imaging of inflamm… View full profile. E-mail: carol.