Maria tokuyama

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Mission Statement: As citizens of the scientific biosphere, we value representation of diverse individuals who advance science and enrich the scientific community. We welcome scientists from underrepresented backgrounds, and as a team, we are committed to reforming institutional culture and policies that perpetuate racism and exclusion in science. Lab Research: The core of our research is to understand how chronic interaction between viruses and the immune system impacts immunity at steady state and during inflammation. We study endogenous retroviruses ERVs , which are viral sequences in our genome that originated from exogenous viruses and have undergone an evolutionary arms race with the host for millions of years. We currently have multiple projects aimed at uncovering how the interaction between ERVs and the immune system impacts antiviral immunity and excessive inflammation in autoimmunity. We rely on multidisciplinary approaches and novel tools in virology, immunology, and computational genomics.

Maria tokuyama

Google Scholar. Tokuyama lab. Tokuyama has always been interested in the interaction between viruses and the immune system. As an undergrad at University of California, Irvine, she worked in an infectious disease lab that focused on HIV research and obtained her B. Tokuyama obtained her Ph. Tokuyama trained at Yale University in the Department of Immunobiology, where she became fascinated by endogenous retroviruses and established the foundation for the research that she will carry out at UBC. In the past year, Dr. The overarching goal of our lab is to identify immunological mechanisms that underlie heterogeneity in disease outcomes. Our lab seeks to understand how interactions between the immune system and the virome influence outcomes of viral infection and autoimmunity. In particular, we are focused on uncovering immunomodulatory functions of endogenous retroviruses ERVs , which are retroviral sequences that make up a large fraction of the human genome.

Office Location. PLoS Biology 18 10e Ultimately, our goal is to identify novel endogenous viral factors that underlie immunity and contribute towards development maria tokuyama immune modulators to treat infections and chronic inflammatory diseases.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. However, it is currently unclear whether results from different tests are comparable. Our recommendation for SARS-CoV-2 diagnostic testing is to select an assay with high sensitivity and that is regionally used, to ease comparability between outcomes. In response, several molecular assays that is, quantitative reverse transcription—PCR RT—qPCR were developed to detect COVID cases 4 , 5 , 6 , 7 ; however, it is not clear to many clinical, research and public health laboratories which assay they should adopt or whether the data are comparable. Independent evaluations of the designed primer—probe sets used in primary SARS-CoV-2 RT—qPCR detection assays are necessary to compare findings across studies and select appropriate assays for in-house testing. Importantly, we did not directly compare the assays per se, as that would have involved many different variables. Our RNA transcripts can thus be used for assay validation, positive controls and standards to quantify viral loads—critical steps for a diagnostic assay.

Maria tokuyama

Since March , severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 has drastically changed our lives and has killed over four million people worldwide. Data analysis from New York City Health found that of all death cases Several research studies have shown that differences in immune response and metabolism during disease may partly explain the worse outcomes in males than females.

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Ongoing Projects Open Close. Try again later. Add co-authors Co-authors. Kidney 2 6 , , Lab Tel. Citations per year. View all. In the past year, Dr. We rely on multidisciplinary approaches and novel tools in virology, immunology, and computational genomics. Using clinical samples, in vivo mouse models and 2D and 3D cell cultures, we seek to uncover how endogenous viral proteins affect immune cell signaling and function in health and disease through transcriptomic, proteomic and functional assays.

Google Scholar. Tokuyama lab.

Ultimately, our goal is to identify novel endogenous viral factors that underlie immunity and contribute towards development of immune modulators to treat infections and chronic inflammatory diseases. For more information: tokuyamalab. Financial Support. Privacy Terms Help. Ultimately, our goal is to identify novel endogenous viral factors that underlie immunity and contribute towards development of immune modulators to treat infections and chronic inflammatory diseases. Sign in. Office Tel. My profile My library Metrics Alerts. As an undergrad at University of California, Irvine, she worked in an infectious disease lab that focused on HIV research and obtained her B. Research Interests. Ongoing Projects Open Close. Research Groups. We currently have multiple projects aimed at uncovering how the interaction between ERVs and the immune system impacts antiviral immunity and excessive inflammation in autoimmunity. Assistant Professor. MedRxiv ,