Ondansetron moa

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Ondansetron moa

Ondansetron , sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy , radiation therapy , or surgery. Common side effects include diarrhea , constipation , headache , sleepiness , and itchiness. Ondansetron was patented in and approved for medical use in Ondansetron is indicated for the prevention of chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting. Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy. It is typically used after other antinausea drugs have failed. A large multi-center cohort study found no association between ondansetron exposure and fetal risk compared to other antiemetic drugs. Ondansetron is one of several antiemetic drugs used during the vomiting phase of cyclic vomiting syndrome. Trials in emergency department settings support the use of ondansetron to reduce vomiting associated with gastroenteritis and dehydration. Its use reduced hospital admissions, but was also associated with higher rates of return visits to the emergency department. Furthermore, people who had initially received ondansetron were more likely to be admitted on the return visit than people who had not received the drug. However, this effect may simply be due to the agent being used more frequently in people who present with more severe illness.

Do not let anyone else take your medication.

Official websites use. Share sensitive information only on official, secure websites. Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT 3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Ondansetron comes as a tablet, a rapidly disintegrating dissolving tablet, film, and an oral solution liquid to take by mouth.

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Ondansetron moa

Excipient information presented when available limited, particularly for generics ; consult specific product labeling. Ondansetron is a selective 5-HT 3 -receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. Surgical patients: Infants and Children: 1 to 4 months: 0.

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J Child Neurol. Safety of clinical practice guideline-recommended antiemetic agents for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric patients: a systematic review and meta-analysis. As such, single doses of injectable ondansetron should not exceed 16 mg at one time. Hosp Pharm. Instead, the best way to dispose of your medication is through a medicine take-back program. Clin Ther. Anecdotally, ototoxicity has also been reported if injected too quickly. Christopher v. However, the clearance is decreased in infants due to the underdeveloped cytochrome P enzyme system. Annals of Emergency Medicine. Patients with Hepatic Impairment: No dose adjustments of ondansetron are necessary for mild to moderate hepatic impairment.

Federal government websites often end in. The site is secure. Its use under these circumstances is both prophylactic and therapeutic.

It is typically used after other antinausea drugs have failed. No specific precautions are required. Prevention of delayed chemotherapy-induced nausea and vomiting after moderately high to highly emetogenic chemotherapy: comparison of ondansetron, prochlorperazine, and dexamethasone. Unless your doctor tells you otherwise, continue your usual diet. Agonists: Ergolines e. Anecdotally, ototoxicity has also been reported if injected too quickly. Breastfeeding Considerations: In a pharmacokinetic study, the relative infant exposure to ondansetron is less. In other projects. Contraindications Ondansetron is contraindicated in patients with hypersensitivity to the drug or any components of it. Store the tablets and rapidly disintegrating tablets away from light, at room temperature or in the refrigerator. Help Accessibility Careers.