Potentiation pharmacology

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Long-term potentiation is widely used as a model for memory formation. Recently, much information concerning this topic like the involvement of protein kinase C, arachidonic acid and N -methyl- d -aspartate receptors has been reported. In this review recent discoveries concerning long-term potentiation and the pharmacological implications for the development of cognition-enhancing drugs are discussed. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions.

Potentiation pharmacology

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Nucleus basalis stimulation facilitates thalamocortical synaptic transmission in the rat auditory cortex. Blumberger1, 2, 3 Robert Chen4 Bruce G.

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Federal government websites often end in. The site is secure. Drug interactions can have desired, reduced or unwanted effects. The probability of interactions increases with the number of drugs taken. The high rate of prescribed drugs in elderly patients year-old patients take an average of 5 drugs increases the likelihood of drug interactions and thus the risk that drugs themselves can be the cause of hospitalization. Drug interactions occur on pharmacodynamic and pharmacokinetic levels.

Potentiation pharmacology

This chapter describes and discusses the differentiation and quantitation of combined effects with respect to synergism or potentiation on the one hand, and antagonism on the other, in complex interactions. In the combinations considered here, the agents exhibit effects in the same direction, when tested singly. Hence, in binary mixtures, both compounds are active. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in via an institution. Unable to display preview.

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Neuropsychopharmacology 34 , — The effects of nootropics on memory. PAS simulates a spike-timing dependent plasticity protocol by combining single-pulse transcranial magnetic stimulation TMS to a cortical area with contralateral peripheral nerve stimulation PNS such as the two stimulations arrive contemporaneously at the targeted cortical area and in turn strengthen the cortical output in response to single-pulse TMS. Brain Res Rev ;— Beukers, M. Thus, the discrepancy may be due to difference in brain region. The administrator of the experiments and participants were blind to drug assignment. EEG recordings from all five time points of the study pre and at time 0, 17, 34 and 60 min post-PAS were then concatenated in order to apply the same objective criteria for cleaning the data. Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus. Muscarinic depression of long-term potentiation in CA3 hippocampal neurons. Neuropsychopharmacology 38 , — Daniel M.

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Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus. Copy to clipboard. Age-related decline in the responsiveness of motor cortex to plastic forces reverses with levodopa or cerebellar stimulation. All analyses was done while blinded and we were only unblinded once the data was finalized. Anyone you share the following link with will be able to read this content:. Given that these drugs are typically administered chronically, future studies should assess the effects of chronic administration. Finally, we did not use auditory masking to control for auditory artifacts due to several reasons. Acta Physiol Scand ;— Vasopressin maintains long-term potentiation in rat lateral septum slices. Frequency-dependent noradrenergic modulation of long-term potentiation in the hippocampus.