Silvadene cream

Silvadene cream silver sulfadiazine is a prescription-only topical medication for treating and preventing severe burn wounds.

Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Silvadene cream

The cream vehicle consists of white petrolatum, stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene glycol, and water, with methylparaben 0. Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated. Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia; dermatologic and allergic reactions, including life-threatening cutaneous reactions [Stevens-Johnson syndrome SJS , toxic epidermal necrolysis TEN and exfoliative dermatitis]; gastrointestinal reactions; hepatitis and hepatocellular necrosis; CNS reactions; and toxic nephrosis.

Keep from silvadene cream. Renal function should be carefully monitored and the urine should be checked for sulfa crystals. How It Works.

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Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital. There is a problem with information submitted for this request. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview. Error Email field is required. Error Include a valid email address. To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information.

Silvadene cream

Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Also, tell your healthcare provider if you're breastfeeding—a severe reaction can occur in infants exposed to sulfa drugs. Silvadene is typically applied once or twice daily and reapplied throughout the day when necessary. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Wound Care Instruction Sheet. The effects of honey compared to silver sulfadiazine for the treatment of burns: a systematic review of randomized controlled trials. If you experience any of the following, it's important to see a healthcare provider:. However, if individual patient requirements make dressings necessary, they may be used. Silvadene's active ingredient, silver sulfadiazine, remains the most commonly used topical applied to the skin medication for burn wound infections. Therefore, in these patients it would be advisable to monitor serum sulfa concentrations. Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Leukopenia and silver sulfadiazine. Advertising and sponsorship policy Advertising and sponsorship opportunities. Old wine in new bottles: silver sulfadiazine nanotherapeutics for burn wound management. The presence of other medical problems may affect the use of this medicine. Rebound to normal leukocyte levels follows onset within 2 to 3 days. Silvadene's side effects are usually mild and limited to the areas where the drug is applied. Int J Burns Trauma. It is very important that you use this medicine only as directed by your doctor. Avoid contact with the eye. Skin Health. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Related Articles.