Spermine

Non-enzymatic glycation between proteins and carbohydrates, such as advanced glycation spermine products AGEsare naturally occurring compounds implicated in aging and numerous degenerative diseases, spermine. Tsutsui, A.

Only showing the first 10 proteins. There are 26 proteins in total. Quantitative metabolomics services for biomarker discovery and validation. Your source for quantitative metabolomics technologies and bioinformatics. You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.

Spermine

Spermidine is a polyamine compound C 7 H 19 N 3 found in ribosomes and living tissues and having various metabolic functions within organisms. It was originally isolated from semen. Spermidine is an aliphatic polyamine. Spermidine synthase SPDS catalyzes its formation from putrescine. It is a precursor to other polyamines, such as spermine and its structural isomer thermospermine. Spermidine is a longevity agent in mammals due to various mechanisms of action, which are just beginning to be understood. Autophagy is the main mechanism at the molecular level, but evidence has been found for other mechanisms, including inflammation reduction, lipid metabolism, and regulation of cell growth, proliferation, and death. Spermidine is known to regulate plant growth, assisting the in vitro process of transcribing RNA, and inhibition of NOS. Also, spermidine is a precursor to other polyamines, such as spermine and thermospermine, some of which contribute to tolerance against drought and salinity in plants. Spermidine has been tested and discovered to encourage hair shaft elongation and lengthen hair growth. Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains.

Source data are provided as a Source Data file. Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. As spermine in Fig, spermine.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer CRC , but the underlying mechanism is incompletely characterized. Targeted disruption of SMS in CRC cells results in spermidine accumulation, which inhibits FOXO3a acetylation and allows subsequent translocation to the nucleus to transcriptionally induce expression of the proapoptotic protein Bim.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Putrescine, spermine, and spermidine are the important polyamines PAs , found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses. PAs are the integrated part of the cellular and genetic metabolism and help in transcription, translation, signaling, and post-translational modifications. At the cellular level, PA concentration may influence the condition of various diseases in the body.

Spermine

Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH.

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Cancer Research. Accepted : 18 July McCloskey, D. Oncogene 33 , — Chaturvedi, R. Calculated H-H distances from the conformers were matched with the averaged internuclear distances from the NOE data and those conformers that fitted were considered as representatives of the solution conformation. Protein Sci. Discovery of metal-binding proteins by thermal proteome profiling Article 26 February General function: Involved in ion transmembrane transporter activity Specific function: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methylphenylpyridinium MPP , tetraethylammonium TEA , Nmethylnicotinamide NMN , 4- 4- dimethylamino styryl - N-methylpyridinium ASP , the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. It was originally isolated from semen. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. It is an essential growth factor in some bacteria as well. Cell spheres were photographed using a Nikon Eclipse Ti-E inverted microscope. Additional information Peer review information Nature Communications thanks the anonymous reviewer s for their contribution to the peer review of this work.

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If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Pharmacological inhibition of spermine oxidase reduces neurodegeneration and improves retinal function in diabetic mice. Primary Handling Editor: Gene Chong. Separation was performed on a Kinetex C18 reversed-phase column 2. Epub May Cite this article Guo, Y. However, SMS deletion in combination with JQ1 treatment synergistically induced Bim expression and apoptosis associated with tumor regression Fig. For several epithelial cancers, strong correlations have been established between chronic inflammation, cancer initiation, and progression, and increased levels of hSMOX, which lead to amplified H 2 O 2 production, oxidative stress, and DNA damage 8 , 16 , 17 , 18 , 19 , This error has now been corrected. Peer reviewer reports are available. The intracellular concentrations of polyamines are maintained within a narrow range through regulation of de novo synthesis, catabolism, and transportation. Received : 03 August ADS Google Scholar. Then Measurement of intracellular polyamines Polyamines were extracted according to the protocol described by Byun et al.