Sv40

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Federal government websites often end in. The site is secure. The polyomavirus simian virus 40 SV40 is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen. A meta-analysis of molecular, pathological, and clinical data from 1, cancer patients indicates that there is a significant excess risk of SV40 associated with human primary brain cancers, primary bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma. Experimental data strongly suggest that SV40 may be functionally important in the development of some of those human malignancies. Therefore, the major types of tumors induced by SV40 in laboratory animals are the same as those human malignancies found to contain SV40 markers.

Sv40

Federal government websites often end in. The site is secure. Since its discovery, simian virus 40 SV40 has been one of the most intensely studied animal viruses. The molecular biology of SV40 has led to seminal discoveries in the fields of transcription, DNA replication, and oncogenic transformation Over the last decade, provocative evidence has accumulated that suggests that SV40 may be a human pathogen. Does SV40 infect humans? If so, when did this monkey polyomavirus enter the human population and where is the reservoir? What is the behavior of SV40 in human cells? Does it cause or contribute to acute or chronic disease? Other comprehensive reviews have also addressed these issues, with a variety of emphases 8 , 10 , 52 , 57 , In , Sweet and Hilleman first described an agent, which they named SV40, that induced cytopathic effects and vacuole formation in monkey cells SV40 was isolated from normal monkey kidney cells, stocks of the Sabin poliovirus vaccine, and an adenovirus vaccine. The last two reagents were prepared in primary kidney cell cultures derived from rhesus monkeys. Subsequent analyses found that the Salk poliovirus vaccine administered from to in the United States was also contaminated with SV40, potentially exposing an estimated million people

Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a sv40 etiologic cofactor, sv40, with specific human tumors.

Infectious Agents and Cancer volume 2 , Article number: 13 Cite this article. Metrics details. Simian virus 40 SV40 is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SVcontaminated vaccines. SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors.

Infectious Agents and Cancer volume 2 , Article number: 13 Cite this article. Metrics details. Simian virus 40 SV40 is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SVcontaminated vaccines. SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors. Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a possible etiologic cofactor, with specific human tumors.

Sv40

Skip to content. Polio vaccines used in the late s and early s were contaminated with a virus called simian virus 40 SV40 present in monkey kidney cells used to grow the vaccine. Subsequently, investigators found SV40 DNA in biopsy specimens obtained from patients with cancers such as mesothelioma lung , osteosarcoma bone and non-Hodgkins lymphoma lymph nodes. However, several facts should be noted:. Taken together, these findings do not support the hypothesis that SV40 virus contained in polio vaccines administered before caused cancers.

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Sollazzo, L. Release of simian virus 40 virions from epithelial cells is polarized and occurs without cell lysis. Oxman, and R. Oncogene 20 : Krynska, K. In this regard, it would be useful to study SV40 infections in immunocompromised individuals. Transgenic mice in which LT expression is regulated by the native viral promoter elements specifically develop tumors of the choroid plexus 6 , the specialized epithelial structure of the brain ependymal lining that produces cerebrospinal fluid. Epidemiologic studies do not show an increased risk of cancers in those who received polio vaccine between and Early transcription gives two spliced RNAs that are both 19s. Rudolph, E. It should be pointed out that, in the recent years, rigorous precautions have been taken in most studies. SV40 is a monkey virus that has now crossed species and infects members of the human population at frequencies that vary in different parts of the world. However, the frequency, natural history, and morbidity of the virus in this increasing patient population are unclear.

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Procopio, L. Simian virus related antigens in three human meningiomas with defined chromosome loss. Lewis, Jr. In other species, particularly hamsters , SV40 causes a variety of tumors, generally sarcomas. That assay detected SV40 antibodies in Italian patients with mesotheliomas 92 , as well as in healthy donors and patients with brain tumors, osteosarcomas, and non-Hodgkin lymphomas Powers, and C. Bibcode : Natur. Increasing evidence for involvement of SV40 in human cancer. Wahlte, G. These results demonstrate the nephrotropic and lymphotropic properties of SV40 and indicate that the kidney can serve as a reservoir for the virus in humans. Population level studies did not show extensive evidence of increase in cancer incidence as a result of exposure, [9] though SV40 has been extensively studied.