Tetrahydroquinoline

Maurya, O. Patel, D. Anand and P.

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Tetrahydroquinoline

Products Items of N- 1,2,3,4-Tetrahydroquinolinecarbonothioyl benzamide. TM Get our latest updates. We use cookies on our website. Some of them are essential, while others help us to improve this website and your experience. Essential Statistics External Media. Accept All Save. Cookie Details Privacy Policy. Accept All Save Back. Essential 1 Essential.

Han, L. Cell Culture Media.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. IN connexion with work on tetrahydroquinoline derivatives of medicinal interest, we have recently synthesized a number of alkoxy- and alkyl-substituted 1,2,3,4-tetrahydroquinolines 1 in which various dialkylaminoalkyl groups carrying in some cases heterocyclic residues such as morpholino, piperidino, etc. Among the compounds tested so far, N -[2- 4-morpholino ethyl]1,2,3,4-tetrahydroquinoline I has shown interesting biological activity.

Tetrahydroquinoline is an organic compound that is the semi-hydrogenated derivative of quinoline. It is a colorless oil. Substituted derivatives of tetrahydroquinoline are common in medicinal chemistry. Tetrahydroquinolines are produced by hydrogenation of quinolines. Because the hydrogenation is reversible, tetrahydroquinoline has been often examined as a hydrogen-donor solvent in coal liquifaction. Using homogeneous catalysts , asymmetric hydrogenation has been demonstrated.

Tetrahydroquinoline

Federal government websites often end in. The site is secure. A review of the recent literature is given focusing on synthetic approaches to 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4 1 H -quinolinones and 4 1 H -quinolinones using domino reactions. These syntheses involve: 1 reduction or oxidation followed by cyclization; 2 S N Ar-terminated sequences; 3 acid-catalyzed ring closures or rearrangements; 4 high temperature cyclizations and 5 metal-promoted processes as well as several less thoroughly studied reactions. Each domino method is presented with a brief discussion of mechanism, scope, yields, simplicity and potential utility. Domino reactions, also known as tandem or cascade reactions, have emerged as a highly effective strategy for the synthesis of bioactive natural products and pharmaceutical agents [ 1 ]. These methods enable chemists to perform complex synthetic conversions with high efficiency using simple starting materials, often via a biomimetic pathway [ 2 ]. Thus, domino reactions contribute immensely to synthetic drug design strategies, enhance aesthetic approaches in total synthesis, and improve yields in large-scale synthesis [ 1 , 2 ]. The advantages of these methods include excellent atom economy, high selectivity, and less waste [ 3 , 4 ]. Additionally, using these strategies, multiple transformations can be carried out in a single laboratory operation without the isolation of intermediates making them prime examples of green chemistry [ 5 , 6 ].

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Chen, H. Cell Based Assays. Search Search articles by subject, keyword or author. CAS Number. Copy to clipboard. H , H , H , H B C 6 F 5 enables a metal-free hydrogenative reduction of substituted N -heteroaromatics using hydrosilanes as reducing agents. Nandi, P. View All PCR. View All Antibodies. The AuNPore catalyst can be readily recovered and reused without any loss of catalytic activity. Customer Service News Quality Certifications. Cell Culture Flasks. Cited by. Email to a Friend.

Xiong, S. Li, B. Fu, J.

Bao, M. The use of NaBH 4 or DDQ in a subsequent step enables the synthesis of tetrahydroquinolines or quinolines, respectively. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. Centrifuge Buckets. Precautionary statements. Rights and permissions Reprints and permissions. Among the compounds tested so far, N -[2- 4-morpholino ethyl]1,2,3,4-tetrahydroquinoline I has shown interesting biological activity. Customers who bought this product also commonly purchased the following combination of items. Accessories and Spare Parts. Hu, Synthesis , , 55 ,