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Tramadol is a prescription medication used to treat moderate to moderately severe pain in adults, white oval pill with 377. Tramadol belongs to a group of drugs called opioid analgesics, which work by blocking pain signals in the body. This medication comes in immediate release tablet and that can be taken up to 6 times a day, with or without food. Tramadol also comes in extended-release tablet and capsule forms and are taken once a day, with or without food.

If you are a consumer or patient please visit this version. Dosage and Administration 2. Warnings and Precautions 5. Tramadol hydrochloride tablets are an opioid agonist indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate 1. Limitations of Use 1. Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options [e. Life-Threatening Respiratory Depression.

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Monitor for signs and symptoms of hyponatremia e.

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Tramadol hydrochloride is the active ingredient present in this pill. It is available in the form of a tablet and belongs to a category of drug called narcotic analgesics, which block the signals causing pain in any part of the body. Get to know how pill works, its side effects, precautions, and contraindications where pills is not suggested. The most common brand name is Ultram. When it is taken in combination with acetaminophen, then it starts working earlier than alone tramadol hydrochloride. It works by altering the way, all types of pain are perceived by the brain and body.

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Because of the risks associated with accidental ingestion, misuse, and abuse, advise patients to store tramadol hydrochloride tablets securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home. Tramadol is a prescription medication used to treat moderate to moderately severe pain. Renal Impairment Impaired renal function results in a decreased rate and extent of excretion of tramadol and its active metabolite, M1. Dosage Modification in Patients with Hepatic Impairment The recommended dose for adult patients with severe hepatic impairment is 50 mg every 12 hours. Deaths due to overdose have been reported with abuse and misuse of tramadol [ see Warnings and Precautions 5. Do not drive or operate heavy machinery until you know how tramadol affects you. Risks From Concomitant Use with Benzodiazepines or Other CNS Depressants Concomitant use of opioids with benzodiazepines or other central nervous system CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Inform patients that anaphylaxis has been reported with ingredients contained in tramadol hydrochloride tablets. Many of these cases were reported in patients taking another drug labeled for QT prolongation, in patients with a risk factor for QT prolongation e. Advise patients not to adjust the dose of tramadol hydrochloride tablets without consulting with a physician or other healthcare professional. Individually titrate tramadol hydrochloride tablets to a dose that provides adequate analgesia and minimizes adverse reactions. Tramadol Overdose Back to Top. Concomitant use of serotonin re-uptake inhibitors and MAO inhibitors may enhance the risk of adverse events, including seizure and serotonin syndrome [see Warnings and Precautions 5. Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of tramadol hydrochloride tablets and know how they will react to the medication [see Patient Counselling Information 17 ]. Nursing Mothers Tramadol is subject to the same polymorphic metabolism as codeine, with ultra-rapid metabolizers of CYP2D6 substrates being potentially exposed to life-threatening levels of the active metabolite O -desmethyltramadol M1.

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Under the requirements of the REMS, drug companies with approved opioid analgesic products must make REMS-compliant education programs available to healthcare providers. The volume of distribution of tramadol was 2. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Healthcare providers are strongly encouraged to complete a REMS compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription [ see Warnings and Precautions 5. Treatment should include evidence-based approaches, such as medication assisted treatment of opioid use disorder. The overall incidence rates of adverse experiences in these trials were similar for tramadol hydrochloride tablets and the active control groups, TYLENOL with Codeine 3 acetaminophen mg with codeine phosphate 30 mg , and aspirin mg with codeine phosphate 30 mg, however, the rates of withdrawals due to adverse events appeared to be higher in the tramadol hydrochloride tablets groups. Advise patients and caregivers that when medicines are no longer needed, they should be disposed of promptly. Monitor neonates exposed to opioid analgesics during labor for signs of excess sedation and respiratory depression. Other signs and symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. The M1 metabolite is more potent than tramadol in mu opioid receptor binding [ see Clinical Pharmacology 12 ]. Alternatively, consider the use of non-opioid analgesics in these patients.