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Tizanidine belongs to a group of medications called muscle relaxants.

Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Tizanidine acts on the central nervous system CNS to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

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If you are a consumer or patient please visit this version. Tizanidine is a central alphaadrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with tizanidine should be reserved for those daily activities and times when relief of spasticity is most important. Because of the short duration of therapeutic effect, treatment with tizanidine should be reserved for those daily activities and times when relief of spasticity is most important [see Dosage and Administration 2. Tizanidine tablets may be prescribed with or without food. Once the formulation has been selected and the decision to take with or without food has been made, this regimen should not be altered. Food has complex effects on tizanidine pharmacokinetics, which differ with the different formulations. Tizanidine capsules and tizanidine tablets are bioequivalent to each other under fasting conditions more than 3 hours after a meal , but not under fed conditions within 30 minutes of a meal. These pharmacokinetic differences may result in clinically significant differences when switching administration of tablet and capsules and when switching administration between the fed or fasted state. These changes may result in increased adverse events, or delayed or more rapid onset of activity, depending upon the nature of the switch. For this reason, the prescriber should be thoroughly familiar with the changes in kinetics associated with these different conditions [see Clinical Pharmacology The recommended starting dose is 2 mg. Because the effect of tizanidine peaks at approximately 1 to 2 hours post-dose and dissipates between 3 to 6 hours post-dose, treatment can be repeated at 6 to 8 hour intervals, as needed, to a maximum of three doses in 24 hours. Dosage can be gradually increased by 2 mg to 4 mg at each dose, with 1 to 4 days between dosage increases, until a satisfactory reduction of muscle tone is achieved. The total daily dose should not exceed 36 mg.

These factors may affect how you should use this medication.

These health issues are also linked to symptoms like muscle rigidity and hypertonia. In these cases, tizanidine hydrochloride is used as a muscle relaxant to mitigate pain. Since it alleviates pain, is tizanidine a narcotic? While narcotics are substances traditionally used to treat pain by binding to receptors in the nervous system — such as opioids - tizanidine is a muscle relaxer. Also known by brand names like Comfort Pac-tizanidine and Zanaflex, tizanidine belongs to a class of drugs called central alphaadrenergic agonists. These drugs work by blocking nerve impulses or pain sensations between the brain and body, specifically pain that occurs around the skeletal muscle areas.

Tizanidine is in a class of drugs called skeletal muscle relaxants. It works by slowing the central nervous system to allow muscles to relax. The U. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Tizanidine belongs to a group of medications called muscle relaxants. Tizanidine is used to treat spasticity , a condition where muscles in your body spasm, cramp, or become tight due to medical problems such as multiple sclerosis or spine injury. Muscle relaxants work by blocking excess firing of the nerve cells that control muscle movement. The benefits of tizanidine are related to its effects on the nervous system. The beneficial effects of tizanidine are noticeable within about one hour of taking the first dose. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

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Tizanidine is used to help relax certain muscles in your body. In these patients, during titration, the individual doses should be reduced. Although 16 mg produced a larger effect, adverse events including hypotension were more common and more severe than in the 8 mg group. The contents herein are for informational purposes only. Stopping the medication: Stopping this medication suddenly can cause increased muscle spasms, an increase in blood pressure, or a rapid heart rate. Depressed cardiac function is also observed including most often bradycardia and hypotension. The events are listed in order of decreasing clinical significance; severity in the post marketing setting is not reported. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Although tizanidine is not addictive like opioids or benzodiazepines are, it can lead to tolerance and physical dependence. The clinical manifestations of tizanidine overdose were consistent with its known pharmacology. Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of tizanidine in the elderly. If your dose is different, do not change it unless your doctor tells you to do so. Drug Label Info. An interaction between two medications does not always mean that you must stop taking one of them. Detox is an important step in addiction recovery because it provides an additional level of support, comfort, and safety during the withdrawal period, which decreases the risk of relapse.

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Tizanidine is closely related to clonidine, which is often abused in combination with narcotics and is known to cause symptoms of rebound upon abrupt withdrawal. Darrin Mangiacarne. Abuse potential was not evaluated in human studies. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Single doses greater than 16 mg have not been studied. There were no differences in the number of spasms occurring in each group. For this reason, the prescriber should be thoroughly familiar with the changes in kinetics associated with these different conditions [see Clinical Pharmacology Tizanidine acts on the central nervous system CNS to produce its muscle relaxant effects. At endpoint the protocol-specified time of outcome assessment , there was a statistically significant reduction in muscle tone and frequency of spasms in the tizanidine treated group compared to placebo. If you do not remember until later, skip the missed dose and continue with your regular dosing schedule. A score of 3 was used to describe considerable increase in tone, making passive movement difficult. The recommended starting dose is 2 mg.