J exp med

Potential mechanisms driving obesity-related inflammation, j exp med, primarily in adipose tissue and other metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts.

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games.

J exp med

Sign In or Create an Account. Search Dropdown Menu. Advanced Search. User Tools Dropdown. Sign In. Skip Nav Destination. Cancer Immunotherapy Update Lymphatic Vessels in Health and Disease Newest Articles. March 06 IL promotes skin autoinflammation. Autoinflammation is marked by IL-1 cytokine overexpression and excessive infiltration by neutrophils. By studying pustular psoriasis, we identify a cascade where neutrophils release IL and trigger skin autoinflammation.

Red cell distribution width: A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis. Xiaoyu Hu: Let the data guide you.

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Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions. Abstract Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age.

J exp med

The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion. Although major cell types have been identified in the mouse intestinal epithelium, cell type-specific markers and functional assignments are largely unavailable for human intestine. Here, our single-cell RNA-seq analyses of 14, epithelial cells from human ileum, colon, and rectum reveal different nutrient absorption preferences in the small and large intestine, suggest the existence of Paneth-like cells in the large intestine, and identify potential new marker genes for human transient-amplifying cells and goblet cells. We have validated some of these insights by quantitative PCR, immunofluorescence, and functional analyses. Furthermore, we show both common and differential features of the cellular landscapes between the human and mouse ilea. Therefore, our data provide the basis for detailed characterization of human intestine cell constitution and functions, which would be helpful for a better understanding of human intestine disorders, such as inflammatory bowel disease and intestinal tumorigenesis.

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The peripheral activity of anti-PD-1 mAb is not fully understood. Leptomeningeal metastasis LM , or spread of cancer to the cerebrospinal fluid CSF and linings of the brain, is a fatal complication of cancer. March 13 Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. All rights reserved. Meningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. Newest Articles. Human neutrophils drive skin autoinflammation by releasing interleukin IL Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. Hidden categories: CS1 errors: periodical ignored Articles with short description Short description is different from Wikidata Monthly journals infobox Articles with outdated impact factors from All articles with failed verification Articles with failed verification from July Official website different in Wikidata and Wikipedia.

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease.

WJEM accepts both solicited and unsolicited manuscripts. Accessed February 23, March 07 March 05 The first issue published by the Rockefeller Institute appeared in February , with Flexner serving as editor, and the journal has been published regularly since then. Most Read Nutrients: Signal 4 in T cell immunity. Download as PDF Printable version. The study shows that rare, damaging variants in lupus patients enable breach of B cell immune tolerance checkpoints and suggests involvement for dysregulated IL-4R signaling and BAFF-R expression. Read Edit View history. The peripheral activity of anti-PD-1 mAb is not fully understood.