Txa medical abbreviation

Giving Tranexamic Acid TXA as soon as possible and no later than 3 hours will help save the lives of trauma victims, women after childbirth, and also reduces bleeding in patients undergoing surgery.

Class: antifibrinolytic agent, antihemophilic agent, hemostatic agent, lysine analog. Tranexamic acid TXA is given intravenously to prevent or reduce bleeding and reduce the need for transfusion during and after tooth extraction in patients with hemophilia. It is also given orally to treat cyclic heavy menstrual bleeding. TXA is used off-label without approval by the U. Food and Drug Administration , most often intravenously for a variety of conditions including prevention or reduction of blood loss during hip, knee, cardiac, facial, and spinal surgery as well as cesarean section and trauma. Used orally off-label for hereditary angioedema HAE , to reduce blood loss during and after prostate surgery, and traumatic hyphema bleeding in the anterior chamber of the eye. Some surgeons use TXA soaked sponges in the surgical field to reduce diffuse bleeding.

Txa medical abbreviation

Thrombosis Journal volume 19 , Article number: 54 Cite this article. Metrics details. We review the evidence for tranexamic acid TXA for the treatment and prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight therapeutic areas where evidence is lacking and discuss safety issues, particularly the concern regarding thrombotic complications. An electronic search was performed in PubMed and the Cochrane Library to identify clinical trials, safety reports and review articles. TXA reduces bleeding in patients with menorrhagia, and in patients undergoing caesarian section, myomectomy, hysterectomy, orthopedic surgery, cardiac surgery, orthognathic surgery, rhinoplasty, and prostate surgery. For dental extractions in patients with bleeding disorders or taking antithrombotic drugs, as well as in cases of idiopathic epistaxis, tonsillectomy, liver transplantation and resection, nephrolithotomy, skin cancer surgery, burn wounds and skin grafting, there is moderate evidence that TXA is effective for reducing bleeding. TXA was not effective in reducing bleeding in traumatic brain injury and upper and lower gastrointestinal bleeding. TXA reduces mortality in patients suffering from trauma and postpartum hemorrhage. For many of these indications, there is no consensus about the optimal TXA dose.

Retrieved 3 June The U. Caution should be exercised when considering TXA for patients with a history of thrombotic events or a familial history of thrombosis.

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Federal government websites often end in. The site is secure. Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes of bleeding are diverse and not always immediately apparent, the availability of a safe, effective, and non-specific hemostatic agent is vital in a wide range of clinical settings, with antifibrinolytic agents often utilized for this purpose. Tranexamic acid TXA is one of the most commonly used and widely researched antifibrinolytic agents; its role in postpartum hemorrhage, menorrhagia, trauma-associated hemorrhage, and surgical bleeding has been well defined. However, the utility of TXA goes beyond these common indications, with accumulating data suggesting its ability to reduce bleeding and improve clinical outcomes in the face of many different hemostatic challenges, without a clear increase in thrombotic risk. Herein, we review the literature and provide practical suggestions for clinical use of TXA across a broad spectrum of bleeding disorders. Antifibrinolytic agents including tranexamic acid TXA have been shown to be effective at preventing bleeding complications in a variety of hemostatic challenges and reduce mortality with minimal adverse effects in some settings. In addition to these well-studied indications, there are numerous other uses of TXA for which evidence is less robust, but clinical benefit has been demonstrated.

Txa medical abbreviation

Tranexamic acid TXA is a medication used to treat or prevent excessive blood loss from major trauma , postpartum bleeding , surgery, tooth removal , nosebleeds , and heavy menstruation. Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen. This decreases the conversion of plasminogen to plasmin, preventing fibrin degradation and preserving the framework of fibrin's matrix structure. Side effects are rare. Tranexamic acid was first made in by Japanese researchers Shosuke and Utako Okamoto. Tranexamic acid is frequently used following major trauma. Tranexamic acid has been found to decrease the risk of death due to any cause in people who have significant bleeding due to trauma. Tranexamic acid is sometimes used to treat heavy menstrual bleeding. Tranexamic acid is sometimes used often in conjunction with oxytocin to reduce bleeding after childbirth.

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Acad Emerg Med. Studies are limited in number, with variable inclusion criteria and evaluative assessments. Systematic review and meta-analysis of the use of tranexamic acid in tonsillectomy. Amaze your friends with your new-found knowledge! Keywords: antifibrinolytic agents, coagulants, fibrin modulating agents, heavy menstrual bleeding, hematologic agents, hematologic disorders, hemophilia, hemorrhage, hemostatic, postpartum hemorrhage, tranexamic acid, trauma. Bone Joint J. Hereditary angioedema HAE is an inherited condition that presents with swelling of the skin or mucosal tissues of the upper respiratory and gastrointestinal tracts and may result in airway compromise. TXA was infused 1 g over 10 min as a loading dose, followed by another 1 g over 8 h. The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: a meta-analysis. J Neurol Neurosurg Psychiatry.

The only FDA-approved usage for tranexamic acid TXA is for heavy menstrual bleeding and short-term prevention in patients with hemophilia. Intravenous TXA is commonly used in severely bleeding patients requiring massive transfusion protocols MTP or when hyper-fibrinolysis is demonstrated.

We excluded studies for only patients with congenital, acquired bleeding disorders, or planned surgical operations. Food and Drug Administration , most often intravenously for a variety of conditions including prevention or reduction of blood loss during hip, knee, cardiac, facial, and spinal surgery as well as cesarean section and trauma. Minerva Anestesiol. Joseph J. Dosing and supporting evidence for each indication is expanded upon in each subsequent section and compiled in Table 1. Topical tranexamic acid as a promising treatment for melasma. The Cochrane Database of Systematic Reviews. Compared to fibrin glue, one study showed significantly less bleeding and transfusion need with TXA [ 96 ], whereas two other studies demonstrated no significant difference in blood loss or the need for transfusion [ 97 , 98 ]. The U. J Oral Maxillofac Surg. Intravenous tranexamic acid reduces blood loss and transfusion requirements after periacetabular osteotomy: A placebo-controlled, double-blind randomized clinical trial. Tranexamic acid in total shoulder arthroplasty and reverse shoulder arthroplasty: a systematic review and meta-analysis. Taken together with the conflicting results of our short systematic review, it is difficult to lead to a conclusion as to whether TXA therapy is related to the risk of thrombotic adverse events or not. Register now or log in to access. TXA reduces mortality in patients suffering from trauma and postpartum hemorrhage.